Affliction can feel like a heavy weight whether it’s unexplained sickness, emotional pain, financial struggle, or spiritual attacks. At times, these battles go beyond the physical and have deep spiritual roots. But take heart God has given us authority to rise above every scheme of the enemy. As Nahum 1:9 declares, “Affliction shall not rise up the second time.” If you’re tired of suffering silently, this blog is for you.
In this article, we’ve compiled 50 powerful prayers against the spirit of affliction, all backed by scripture, to help you fight back in faith. Whether you’re praying for healing, deliverance, or breakthrough, each prayer is a weapon in your hands. Speak them boldly, believe with your heart, and trust that God will move in your situation.
What Is the Spirit of Affliction According to the Bible?
The spirit of affliction in the Bible refers to deep suffering that can touch not just the body, but also the mind, emotions, and soul. It often shows up as sickness, depression, failure, rejection, or constant hardship. While some afflictions may appear physical or circumstantial, the Bible reveals that many are rooted in spiritual attacks.
In Psalm 34:19, the Word says, “Many are the afflictions of the righteous, but the Lord delivers him out of them all.” This verse reminds us that even faithful believers can suffer, but deliverance is always available through God.
We also see in Luke 13:11 a woman afflicted for 18 years by a “spirit of infirmity.” Her condition wasn’t just medical it had a demonic source. Jesus delivered her with a word.
This shows that the spirit of affliction is real, but so is our authority in Christ to overcome it.
Why You Must Pray Against the Spirit of Affliction
5 Reasons You Must Resist Affliction Spiritually
1. It Weakens Your Faith:
Affliction often comes with discouragement, making you doubt God’s promises and feel spiritually dry. Prayer keeps your faith alive and strong.
2. It Steals Your Destiny:
Prolonged suffering can distract or delay you from fulfilling your God-given purpose. That’s why you must rise in prayer and claim restoration.
3. It Causes Delay and Bondage:
Many afflictions are rooted in invisible chains cycles of defeat, delay, and spiritual stagnation. Only prayer can break what the eyes cannot see.
4. It Has a Hidden Demonic Root:
As in the Bible, some afflictions are spiritually programmed. Without spiritual warfare, the real source remains untouched and keeps returning.
5. God Has Given You Authority to Break It:
Luke 10:19 says you have power over all the works of the enemy. When you pray in Jesus’ name, affliction loses its grip on your life.
Scriptures to Defeat the Spirit of Affliction
God’s Word is a powerful weapon against every spiritual attack. Below are key scriptures to defeat the spirit of affliction, each filled with promise, authority, and healing:
Isaiah 53:5
“But He was wounded for our transgressions… and by His stripes we are healed.”
This verse reminds us that Jesus already paid the price for our healing. Affliction has no legal right over a redeemed life.
Jeremiah 30:17
“For I will restore health to you and heal you of your wounds, declares the Lord.”
God doesn’t just heal He restores. No matter how long you’ve suffered, restoration is still possible.
Psalm 34:19
“Many are the afflictions of the righteous, but the Lord delivers him out of them all.”
Afflictions may come, but God’s deliverance is guaranteed when we trust and call on Him.
Luke 13:11–13
“…a woman had a spirit of infirmity eighteen years… and immediately she was made straight.”
Affliction can be spiritual. Jesus has the authority to instantly break every demonic stronghold.
2 Corinthians 10:4
“The weapons of our warfare are not carnal but mighty through God…”
Prayer, scripture, and fasting are spiritual weapons that destroy the root of every affliction.
Nahum 1:9
“Affliction shall not rise up the second time.”
God doesn’t just heal He permanently closes the door to recurring pain and bondage.
Exodus 23:25
“I will take away sickness from among you.”
Worship and obedience invite divine protection. Affliction flees where God is truly honored.
How to Pray These Prayers for Results
If you’re wondering how to pray against the spirit of affliction, know this: effective prayer isn’t about long words, but about faith, alignment, and persistence.
First, pray with faith believe that God is listening and willing to deliver you. Doubt weakens spiritual authority. Next, use scripture while praying. Quoting God’s Word builds spiritual power and aligns your heart with heaven.
Repent of any known sin unconfessed sin can give the enemy legal ground to afflict. Keep your heart pure and humble before God. For deeper breakthroughs, consider fasting it sharpens your spiritual sensitivity and helps break stubborn yokes.
Finally, apply anointing oil as a prophetic act of healing and consecration, just as it was used in the Bible.
Don’t give up. Keep declaring God’s promises daily. Affliction may be strong, but your God is stronger and your prayers are working behind the scenes.
50 Powerful Prayers Against the Spirit of Affliction
1. Prayers for Physical Healing from Affliction
1. Heavenly Father, by Your stripes I declare healing over every sickness in my body. Affliction has no authority over me I receive Your strength and wholeness in Jesus’ name.
2. Lord, I reject every root of infirmity in my blood, bones, and organs. Let Your healing power flow through every cell and restore me completely.
3. Jesus, I command every pain, disease, and chronic condition to leave my body now. You are my Healer, and I claim divine health through Your blood.
4. Lord, I speak life and restoration into every part of my body attacked by affliction. Let the fire of the Holy Spirit burn away every trace of sickness.
5. Father, I declare that affliction shall not rise again in my health. I walk in divine wellness and freedom according to Your Word in Nahum 1:9.
6. Jesus, I cancel every diagnosis spoken against my life. Your Word says I am healed so I believe it, declare it, and receive it today.
7. Lord, I anoint my body with Your presence. Let every affliction hiding in my flesh be exposed and destroyed by Your mighty power.
8. Father, I declare that no sickness will cut short my destiny. I shall live and not die, and I will declare the works of the Lord.
9. Jesus, I renounce every curse of weakness, pain, and fatigue. Fill me with supernatural energy and divine health all my days.
10. Lord, release Your healing angels over me now. Let every hidden affliction be flushed out and every demonic deposit be uprooted in Jesus’ name.
2. Prayers Against Emotional and Mental Affliction
11. Father, I surrender every heavy emotion fear, depression, anxiety at Your feet. Flood my heart with peace that surpasses all understanding.
12. Jesus, I rebuke every tormenting spirit attacking my mind. Let the blood of Jesus cleanse my thoughts and renew my inner strength.
13. Lord, I cast down every lie of the enemy that says I am worthless or forgotten. I am fearfully and wonderfully made in Your image.
14. Heavenly Father, restore joy where sorrow has taken root. Heal the wounds I carry inside, and fill my soul with fresh hope and gladness.
15. Jesus, I break every chain of insomnia, panic, and emotional torment. Let Your perfect love drive out all fear in my life.
16. Lord, guard my mind like a fortress. Let no affliction invade my peace. I claim the mind of Christ and victory over every mental battle.
17. Father, I silence every voice whispering defeat, rejection, and shame. I listen only to Your voice, which speaks love and purpose over me.
18. Jesus, hold my heart in Your hands. Where trauma left a scar, bring Your healing touch and restore my confidence in You.
19. Lord, I renounce every spirit of confusion and restlessness. I walk in clarity, soundness, and peace from the Holy Spirit.
20. Father, wrap me in Your comfort today. Let Your presence be my therapy, my rest, and my restoration from emotional affliction.
3. Prayers to Break Generational Curses & Bondage
21. Father, I break every generational curse of affliction operating in my bloodline. I am redeemed by the blood of Jesus and walk in liberty.
22. Jesus, I renounce every ancestral agreement that has given the enemy access to my life. I declare freedom from inherited bondage.
23. Lord, let the power in the name of Jesus destroy every demonic pattern of sickness, poverty, or delay passed through generations.
24. Father, I sever every soul tie connecting me to the afflictions of my ancestors. Let every ungodly covenant be broken now.
25. Jesus, I take back everything the enemy has stolen through generational manipulation. I recover my blessings and declare total restoration.
26. Lord, let every altar raised against my family lineage catch fire. No weapon formed against my bloodline shall prosper again.
27. Father, I plead the blood of Jesus over my family tree. I plant a new legacy of health, favor, and spiritual strength in Christ.
28. Jesus, I close every door my forefathers opened to the enemy through sin or idolatry. Today, I walk in a new covenant with You.
29. Lord, I cancel every generational curse of miscarriage, barrenness, or chronic illness. I decree divine fruitfulness over my future.
30. Father, my inheritance is in Christ, not in curses. I walk in blessing, peace, and generational breakthrough from this day forward.
4. Prayers for Deliverance from Demonic Oppression
31. Jesus, I command every unclean spirit of affliction tormenting my life to leave now! I am delivered by the power of Your name.
32. Father, surround me with Your angels of war. Let every demonic power attacking my health, mind, or peace be scattered today.
33. Lord, I destroy every yoke of oppression placed upon me through dreams, covenants, or demonic contact. I am free in Christ!
34. Jesus, I break every spell, hex, or charm working against my destiny. Let Your blood silence every evil voice speaking affliction.
35. Father, I shut down every demonic gate that gives access to affliction in my life. I cover every door with the blood of Jesus.
36. Lord, arise and scatter every gathering of darkness planning my downfall. Let their plans backfire and be turned to dust.
37. Jesus, I take authority over every monitoring spirit sent to report on my life. I blind their eyes and command confusion in their camp.
38. Father, let every spiritual chain tying me to bondage be broken. I walk out of every prison into the freedom of Christ.
39. Lord, fill me with the fire of the Holy Spirit. Let every evil presence flee from my home, body, and surroundings immediately.
40. Jesus, I declare that no affliction demon shall rise again. I am covered, filled, and surrounded by Your glory forever.
5. Prayers for Restoration, Peace, and Victory
41. Father, restore everything that affliction tried to steal my peace, my health, my time, and my destiny. I receive double for my trouble.
42. Jesus, I decree divine acceleration in every delayed area of my life. What took years will now happen in months by Your power.
43. Lord, fill me with peace like a river. I will not live in fear, anxiety, or torment I walk boldly in Your divine rest.
44. Father, I reclaim my joy and declare that my mourning has turned into dancing. Affliction shall not rise again!
45. Jesus, grant me victory over every battle I’ve faced. My testimony will be louder than my pain, and my story will glorify You.
46. Lord, breathe new life into every dry and dead situation. Let resurrection power flow through my finances, family, and calling.
47. Father, thank You for divine favor. Every door that affliction closed You will reopen with greater blessings behind it.
48. Jesus, I walk in authority and power today. No force of darkness can defeat me I am a conqueror through Your name.
49. Lord, fill my heart with unshakable faith and calm. Let storms around me cease as I rest under Your wings.
50. Father, I celebrate my deliverance. Affliction has lost its grip, and I rise today in strength, victory, and unshakable joy!
FAQs: About Prayers Against the Spirit of Affliction
How to pray against affliction?
To pray against affliction, start by declaring God’s Word with faith. Use scriptures like Nahum 1:9 and Isaiah 53:5. Speak healing, break every curse, and ask for the Holy Spirit’s fire to destroy every root of suffering.
What is the spirit of affliction?
The spirit of affliction is a demonic force that brings ongoing pain, sickness, emotional heaviness, or setbacks. It often hides behind physical symptoms but originates from spiritual oppression.
How to break the spirit of infirmity?
Break the spirit of infirmity through prayer, fasting, repentance, and declaring healing scriptures. Rebuke the affliction in Jesus’ name and anoint yourself with oil as a sign of deliverance and restoration.
How to overcome an affliction?
You overcome affliction by trusting in God’s promises, praying persistently, and refusing to give in to fear. Stand firm in faith, confess healing daily, and declare: “Affliction shall not rise again!”
Conclusion – Declare Your Freedom Today
You were not created to live under the weight of affliction. Jesus has already paid the price for your healing, your peace, and your victory. As Nahum 1:9 reminds us, “Affliction shall not rise up the second time.” Let that promise be your daily declaration. Stand on God’s Word, pray boldly, and expect total restoration in every area of your life. No matter how long the battle has been, today marks a turning point. Keep speaking life, keep trusting, and remember:
“Affliction shall not rise again!”
“Are you or someone you love battling affliction? Bookmark these 50 prayers and declare them daily. God’s power will bring healing and freedom in Jesus’ name.”